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106 4. In addition, the key components of the Neurokinin A 1 2 34 5 6 7 Transcription; Alternate int of RNA β-PPT mRNA Translation Exons 2,3,4,5,6,7 (all) Post-translational processing Substance P -NH2 Neurokinin A -NH2 Neurokinin A(3-10) -NH2 Neuropeptide K -NH2 γ-PPT mRNA Translation Exons 2,3,5,6,7 (not 4) Post-translational processing Substance P -NH2 Neurokinin A -NH2 Neurokinin A(3-10) -NH2 Neuropeptide γ -NH2 α-PPT mRNA Translation Exons 2,3,4,5,7 (not 6) Post-translational processing Substance P -NH2 F I G U R E 1 8 - 9 Several mechanisms through which the substance P gene gives rise to splicing of mRNA leads to translation of distinct precursors, and subsequent processing leads to unique mature peptides.
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